Clinical Analysis Dysgerminoma of 57 Patients with Ovarian

Received March 20, 2004; accepted May 28, 2004, Chinese Journal of Clinical Oncotgy Email: COCR~evou.com TelIFax): 86-22-2352-2919 OBJECTIVE Ovarian dysgerminoma is an uncommon ovarian malignancy. Its clinical features are special and there are many factors affecting its prognosis, tf treated properly, the patient can be cured. Otherwise it may endanger the patient's life. The aim of this study is to investigate the clinical features and factors related to prognosis of ovarian dysgerminoma. METHODS Data from 57 patients with pure ovarian dysgerminoma were analyzed retrospectively. The patients were admitted to the Cancer Center, Sun Yat-sen University from January 1,1964 to December 31,2000. RESULTS The main clinical features were abdominal mass (56.1% ~, abdominal pain ~21.1% ), abdominal swelling (17.5%), vagina! bleeding !15.3% )and genital tract abnormalities (6.3%). Twenty-six patients had stage I diseases,8 stage 11,9 stage II1.1 stage tV and 13 recurrent and persistent diseases. The uterus was involved in 41.2% of patients with stage II-tl l diseases. Combined modality was given to 52 cases and a singlemethod treatment to 5 cases. The total overall 5 and 10-year survival rates for stages I-IV was 80. I% and 70.0% respectively. The 5-year survival rate for stage I was 100%, stage II 55.2% ,stage III 55.6% and stage tV 0% ;for recurrent and persistent diseases, 72.7%. The stage I group of 12 patients. received adnexectomy and 14 patients underwent hysterectomy and adnexa removal. There was no significant difference between the 5 and 10year survival rates (all 100%). Of the 23 patients in tt~e stage I group to whom only chemotherapy was given after operation, 19 cases receiw~d 3 or more courses and were wen without recurrence; 4 patients received only one course and one of tt~em recurred 21 months after the operation. In the group of stages It and III cases, the 5--year survival rate was 86.7% for those whose ctlemotherapy courses were->-'4 and 26.0% for patients who received less than 4 courses ol chemotherapy (P<0.05). CONCLUSIONS The prognosis of ovarian dysgerminoma is closely related to the disease stage and treatment modality A fertility-preserving operation can be considered in early--staged patients, but caution needs to be exercised in the middle to late staged cases. Good results can be achieved with an operation-based combined modafity in recurrent patients.